Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain

HSJ1 (DNAJB2), a member of the DNAJ family of molecular chaperones, is a key player in neuronal proteostasis maintenance. It binds ubiquitylated proteins through its Ubiquitin Interacting Motifs (UIMs) and facilitates their delivery to the proteasome for degradation. Mutations in the DNAJB2 gene lea...

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Publicat a:Hum Mol Genet
Autors principals: Ottaviani, Daniele, Marin, Oriano, Arrigoni, Giorgio, Franchin, Cinzia, Vilardell, Jordi, Sandre, Michele, Li, Wenwen, Parfitt, David A., Pinna, Lorenzo A., Cheetham, Michael E., Ruzzene, Maria
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409130/
https://ncbi.nlm.nih.gov/pubmed/28031292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw420
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