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An Unconventional Acid-Labile Nucleobase Protection Concept for Guanosine Phosphoramidites in RNA Solid-Phase Synthesis

We present an innovative O(6)-tert-butyl/N(2)-tert-butyloxycarbonyl protection concept for guanosine (G) phosphoramidites. This concept is advantageous for 2′-modified G building blocks because of very efficient synthetic access when compared with existing routes that usually employ O(6)-(4-nitrophe...

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Bibliografiske detaljer
Udgivet i:Chemistry
Main Authors: Jud, Lukas, Micura, Ronald
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408931/
https://ncbi.nlm.nih.gov/pubmed/27943429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201605056
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