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An Unconventional Acid-Labile Nucleobase Protection Concept for Guanosine Phosphoramidites in RNA Solid-Phase Synthesis
We present an innovative O(6)-tert-butyl/N(2)-tert-butyloxycarbonyl protection concept for guanosine (G) phosphoramidites. This concept is advantageous for 2′-modified G building blocks because of very efficient synthetic access when compared with existing routes that usually employ O(6)-(4-nitrophe...
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| Gepubliceerd in: | Chemistry |
|---|---|
| Hoofdauteurs: | , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5408931/ https://ncbi.nlm.nih.gov/pubmed/27943429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201605056 |
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