Structure of nascent chromatin is essential for hematopoietic lineage specification

The role of chromatin structure in lineage commitment of multipotent hematopoietic progenitors (HPCs) is presently unclear. We show here that CD34+ HPCs possess a post-replicative chromatin globally devoid of the repressive histone mark H3K27me3. This H3K27-unmodified chromatin is required for recru...

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Publicado en:Cell Rep
Autores principales: Petruk, Svetlana, Mariani, Samanta A., De Dominici, Marco, Porazzi, Patrizia, Minieri, Valentina, Cai, Jingli, Iacovitti, Lorraine, Flomenberg, Neal, Calabretta, Bruno, Mazo, Alexander
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408750/
https://ncbi.nlm.nih.gov/pubmed/28402853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.03.035
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