CDKN2A-independent role of BMI1 in promoting growth and survival of Ph+ acute lymphoblastic leukemia

BMI1 is a key component of the PRC1 complex (polycomb repressive complex-1) required for maintenance of normal and cancer stem cells. Its aberrant expression is detected in chronic myeloid leukemia and Ph+ acute lymphoblastic leukemia (ALL), but no data exist on BMI1 requirement in ALL cells. We sho...

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Publicado en:Leukemia
Main Authors: Mariani, Samanta Antonella, Minieri, Valentina, De Dominici, Marco, Iacobucci, Ilaria, Peterson, Luke F., Calabretta, Bruno
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972639/
https://ncbi.nlm.nih.gov/pubmed/27125204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.70
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