Targeting STAT5 or STAT5-regulated pathways suppresses leukemogenesis of Ph+ acute lymphoblastic leukemia

Combining standard cytotoxic chemotherapy with BCR-ABL1 tyrosine kinase inhibitors (TKI) has greatly improved the upfront treatment of patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). However, prognosis remains poor due to the development of drug resistance th...

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Bibliografske podrobnosti
izdano v:Cancer Res
Main Authors: Minieri, Valentina, De Dominici, Marco, Porazzi, Patrizia, Mariani, Samanta A., Spinelli, Orietta, Rambaldi, Alessandro, Peterson, Luke F., Porcu, Pierluigi, Nevalainen, Marja, Calabretta, Bruno
Format: Artigo
Jezik:Inglês
Izdano: 2018
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7100125/
https://ncbi.nlm.nih.gov/pubmed/30154155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-0195
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