Runx1 Orchestrates Sphingolipid Metabolism and Glucocorticoid Resistance in Lymphomagenesis

The three‐membered RUNX gene family includes RUNX1, a major mutational target in human leukemias, and displays hallmarks of both tumor suppressors and oncogenes. In mouse models, the Runx genes appear to act as conditional oncogenes, as ectopic expression is growth suppressive in normal cells but dr...

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Veröffentlicht in:J Cell Biochem
Hauptverfasser: Kilbey, A., Terry, A., Wotton, S., Borland, G., Zhang, Q., Mackay, N., McDonald, A., Bell, M., Wakelam, M.J.O., Cameron, E.R., Neil, J.C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408393/
https://ncbi.nlm.nih.gov/pubmed/27869314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.25802
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