Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells

Long-range cis-regulatory elements such as enhancers coordinate cell-specific transcriptional programmes by engaging in DNA looping interactions with target promoters. Deciphering the interplay between the promoter connectivity and activity of cis-regulatory elements during lineage commitment is cru...

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Detalles Bibliográficos
Publicado en:eLife
Autores principales: Freire-Pritchett, Paula, Schoenfelder, Stefan, Várnai, Csilla, Wingett, Steven W, Cairns, Jonathan, Collier, Amanda J, García-Vílchez, Raquel, Furlan-Magaril, Mayra, Osborne, Cameron S, Fraser, Peter, Rugg-Gunn, Peter J, Spivakov, Mikhail
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407860/
https://ncbi.nlm.nih.gov/pubmed/28332981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21926
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