Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H).

Anti-phospholipid (aPL) antibodies that exhibit binding in cardiolipin (CL) ELISA can be purified to greater than 95% purity by sequential phospholipid affinity and ion-exchange chromatography. However, these highly purified aPL antibodies do not bind to the CL antigen when assayed by a modified CL...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	McNeil, H P, Simpson, R J, Chesterman, C N, Krilis, S A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1990
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54059/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2349221/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.11.4120
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