Sheet-Like Remodeling of the Transverse Tubular System in Human Heart Failure Impairs Excitation-Contraction Coupling and Functional Recovery by Mechanical Unloading

BACKGROUND: Cardiac recovery in response to mechanical unloading by left ventricular assist devices (LVADs) has been demonstrated in subgroups of chronic heart failure (HF) patients. Hallmarks of HF are depletion and disorganization of the transverse tubular system (t-system) in cardiomyocytes. Here...

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Publicado en:Circulation
Autores principales: Seidel, Thomas, Navankasattusas, Sutip, Ahmad, Azmi, Diakos, Nikolaos A., Xu, Weining David, Tristani-Firouzi, Martin, Bonios, Michael J., Taleb, Iosif, Li, Dean Y., Selzman, Craig H., Drakos, Stavros G., Sachse, Frank B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404964/
https://ncbi.nlm.nih.gov/pubmed/28073805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.116.024470
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