Sheet-Like Remodeling of the Transverse Tubular System in Human Heart Failure Impairs Excitation-Contraction Coupling and Functional Recovery by Mechanical Unloading

BACKGROUND: Cardiac recovery in response to mechanical unloading by left ventricular assist devices (LVADs) has been demonstrated in subgroups of chronic heart failure (HF) patients. Hallmarks of HF are depletion and disorganization of the transverse tubular system (t-system) in cardiomyocytes. Here...

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Gepubliceerd in:Circulation
Hoofdauteurs: Seidel, Thomas, Navankasattusas, Sutip, Ahmad, Azmi, Diakos, Nikolaos A., Xu, Weining David, Tristani-Firouzi, Martin, Bonios, Michael J., Taleb, Iosif, Li, Dean Y., Selzman, Craig H., Drakos, Stavros G., Sachse, Frank B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404964/
https://ncbi.nlm.nih.gov/pubmed/28073805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.116.024470
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