Novel Bacterial Topoisomerase Inhibitors with Potent Broad-Spectrum Activity against Drug-Resistant Bacteria

The novel bacterial topoisomerase inhibitor class is an investigational type of antibacterial inhibitor of DNA gyrase and topoisomerase IV that does not have cross-resistance with the quinolones. Here, we report the evaluation of the in vitro properties of a new series of this type of small molecule...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Charrier, Cédric, Salisbury, Anne-Marie, Savage, Victoria J., Duffy, Thomas, Moyo, Emmanuel, Chaffer-Malam, Nathan, Ooi, Nicola, Newman, Rebecca, Cheung, Jonathan, Metzger, Richard, McGarry, David, Pichowicz, Mark, Sigerson, Ralph, Cooper, Ian R., Nelson, Gary, Butler, Hayley S., Craighead, Mark, Ratcliffe, Andrew J., Best, Stuart A., Stokes, Neil R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404544/
https://ncbi.nlm.nih.gov/pubmed/28223393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02100-16
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