Efficacy of a Novel Tricyclic Topoisomerase Inhibitor in a Murine Model of Neisseria gonorrhoeae Infection

There is an urgent need for new antibiotics to treat multidrug-resistant Neisseria gonorrhoeae. In this report, the microbiology, in vivo pharmacokinetics, and efficacy of REDX05931, a representative novel tricyclic topoisomerase inhibitor, were evaluated. REDX05931 demonstrated high oral bioavailab...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Savage, Victoria J., Charrier, Cédric, Salisbury, Anne-Marie, Box, Helen, Chaffer-Malam, Nathan, Huxley, Anthony, Kirk, Ralph, Noonan, Gary M., Mohmed, Sarfraz, Craighead, Mark W., Ratcliffe, Andrew J., Best, Stuart A., Stokes, Neil R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4997832/
https://ncbi.nlm.nih.gov/pubmed/27324777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00913-16
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