Molecular Confirmation of the Relationship between Candida guilliermondii Fks1p Naturally Occurring Amino Acid Substitutions and Its Intrinsic Reduced Echinocandin Susceptibility

Candida guilliermondii shows intrinsic reduced echinocandin susceptibility. It harbors two polymorphisms (L633M and T634A) in the Fks1p hot spot 1 region. Our objective was to confirm that the reduced echinocandin susceptibility of C. guilliermondii is due to those naturally occurring substitutions....

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Dudiuk, Catiana, Macedo, Daiana, Leonardelli, Florencia, Theill, Laura, Cabeza, Matias S., Gamarra, Soledad, Garcia-Effron, Guillermo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404515/
https://ncbi.nlm.nih.gov/pubmed/28242659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02644-16
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