FDG metabolism associated with tau-amyloid interaction predicts memory decline

OBJECTIVE: To evaluate in normal older adults and preclinical Alzheimer’s disease (AD) the impact of amyloid and regional tauopathy on cerebral glucose metabolism and subsequent memory decline. METHODS: We acquired positron emission tomography using F18 Flortaucipir (tau), C11 Pittsburgh Compound B...

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Udgivet i:Ann Neurol
Main Authors: Hanseeuw, Bernard J., Betensky, Rebecca A., Schultz, Aaron P., Papp, Kate V., Mormino, Elizabeth C., Sepulcre, Jorge, Bark, John S., Cosio, Danielle M., LaPoint, Molly, Chhatwal, Jasmeer P., Rentz, Dorene M., Sperling, Reisa A., Johnson, Keith
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404378/
https://ncbi.nlm.nih.gov/pubmed/28253546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24910
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