Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity

Animal studies demonstrate that hyperactive neurons facilitate early accumulation and spread of tau and amyloid-β proteins in the pathological cascade of Alzheimer's disease (AD). Human neuroimaging studies have linked hippocampal hyperactivity to amyloid-β accumulation, apolipoprotein ε4 (APOE...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Huijbers, Willem, Schultz, Aaron P., Papp, Kathryn V., LaPoint, Molly R., Hanseeuw, Bernard, Chhatwal, Jasmeer P., Hedden, Trey, Johnson, Keith A., Sperling, Reisa A.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2019
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6335746/
https://ncbi.nlm.nih.gov/pubmed/30482786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1397-18.2018
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