Benzylideneoxymorphone: A new lead for development of bifunctional mu/delta opioid receptor ligands

Opioid analgesic tolerance remains a considerable drawback to chronic pain management. The finding that concomitant administration of delta opioid receptor (DOR) antagonists attenuates the development of tolerance to mu opioid receptor (MOR) agonists has led to interest in producing bifunctional MOR...

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Udgivet i:Bioorg Med Chem Lett
Main Authors: Healy, Jason R., Bezawada, Padmavani, Griggs, Nicholas W., Devereaux, Andrea L., Matsumoto, Rae R., Traynor, John R., Coop, Andrew, Cunningham, Christopher W.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404377/
https://ncbi.nlm.nih.gov/pubmed/28011222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.11.057
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