Benzylideneoxymorphone: A new lead for development of bifunctional mu/delta opioid receptor ligands

Opioid analgesic tolerance remains a considerable drawback to chronic pain management. The finding that concomitant administration of delta opioid receptor (DOR) antagonists attenuates the development of tolerance to mu opioid receptor (MOR) agonists has led to interest in producing bifunctional MOR...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Healy, Jason R., Bezawada, Padmavani, Griggs, Nicholas W., Devereaux, Andrea L., Matsumoto, Rae R., Traynor, John R., Coop, Andrew, Cunningham, Christopher W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404377/
https://ncbi.nlm.nih.gov/pubmed/28011222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.11.057
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