Systemic injection of AAV9-GDNF provides modest functional improvements in the SOD1(G93A) ALS rat but has adverse side effects

Injecting proteins into the central nervous system that stimulate neuronal growth can lead to beneficial effects in animal models of disease. In particular, glial cell line-derived neurotrophic factor (GDNF) has shown promise in animal and cell models of Parkinson's disease, Huntington's d...

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Bibliografiske detaljer
Udgivet i:Gene Ther
Main Authors: Thomsen, G M, Alkaslasi, M, Vit, J-P, Lawless, G, Godoy, M, Gowing, G, Shelest, O, Svendsen, C N
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
Fag:
Short Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404206/
https://ncbi.nlm.nih.gov/pubmed/28276446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2017.9
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