Delayed Disease Onset and Extended Survival in the SOD1(G93A) Rat Model of Amyotrophic Lateral Sclerosis after Suppression of Mutant SOD1 in the Motor Cortex

Sporadic amyotrophic lateral sclerosis (ALS) is a fatal disease with unknown etiology, characterized by a progressive loss of motor neurons leading to paralysis and death typically within 3–5 years of onset. Recently, there has been remarkable progress in understanding inherited forms of ALS in whic...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Thomsen, Gretchen M., Gowing, Genevieve, Latter, Jessica, Chen, Maximus, Vit, Jean-Philippe, Staggenborg, Kevin, Avalos, Pablo, Alkaslasi, Mor, Ferraiuolo, Laura, Likhite, Shibi, Kaspar, Brian K., Svendsen, Clive N.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298650/
https://ncbi.nlm.nih.gov/pubmed/25411487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2037-14.2014
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