Systemic injection of AAV9-GDNF provides modest functional improvements in the SOD1(G93A) ALS rat but has adverse side effects

Injecting proteins into the central nervous system that stimulate neuronal growth can lead to beneficial effects in animal models of disease. In particular, glial cell line-derived neurotrophic factor (GDNF) has shown promise in animal and cell models of Parkinson's disease, Huntington's d...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Gene Ther
Päätekijät: Thomsen, G M, Alkaslasi, M, Vit, J-P, Lawless, G, Godoy, M, Gowing, G, Shelest, O, Svendsen, C N
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2017
Aiheet:
Short Communication
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404206/
https://ncbi.nlm.nih.gov/pubmed/28276446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2017.9
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