Systemic injection of AAV9-GDNF provides modest functional improvements in the SOD1(G93A) ALS rat but has adverse side effects

Injecting proteins into the central nervous system that stimulate neuronal growth can lead to beneficial effects in animal models of disease. In particular, glial cell line-derived neurotrophic factor (GDNF) has shown promise in animal and cell models of Parkinson's disease, Huntington's d...

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Spremljeno u:
Bibliografski detalji
Izdano u:Gene Ther
Glavni autori: Thomsen, G M, Alkaslasi, M, Vit, J-P, Lawless, G, Godoy, M, Gowing, G, Shelest, O, Svendsen, C N
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Short Communication
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404206/
https://ncbi.nlm.nih.gov/pubmed/28276446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2017.9
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