Systemic injection of AAV9-GDNF provides modest functional improvements in the SOD1(G93A) ALS rat but has adverse side effects

Injecting proteins into the central nervous system that stimulate neuronal growth can lead to beneficial effects in animal models of disease. In particular, glial cell line-derived neurotrophic factor (GDNF) has shown promise in animal and cell models of Parkinson's disease, Huntington's d...

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Detalhes bibliográficos
Publicado no:Gene Ther
Main Authors: Thomsen, G M, Alkaslasi, M, Vit, J-P, Lawless, G, Godoy, M, Gowing, G, Shelest, O, Svendsen, C N
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404206/
https://ncbi.nlm.nih.gov/pubmed/28276446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2017.9
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