Glial cell line-derived neurotrophic factor-secreting human neural progenitors show long-term survival, maturation into astrocytes, and no tumor formation following transplantation into the spinal cord of immunocompromised rats

Human neural progenitor cells (hNPCs) derived from the fetal cortex can be expanded in vitro and genetically modified through lentiviral transduction to secrete growth factors shown to have a neurotrophic effect in animal models of neurological disease. hNPCs survive and mature following transplanta...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gowing, Geneviève, Shelley, Brandon, Staggenborg, Kevin, Hurley, Amanda, Avalos, Pablo, Victoroff, Jesse, Latter, Jessica, Garcia, Leslie, Svendsen, Clive N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Lippincott Williams & Wilkins 2014
Pynciau:
Engineered Cells
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969154/
https://ncbi.nlm.nih.gov/pubmed/24284956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/WNR.0000000000000092
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