Glial cell line-derived neurotrophic factor-secreting human neural progenitors show long-term survival, maturation into astrocytes, and no tumor formation following transplantation into the spinal cord of immunocompromised rats

Human neural progenitor cells (hNPCs) derived from the fetal cortex can be expanded in vitro and genetically modified through lentiviral transduction to secrete growth factors shown to have a neurotrophic effect in animal models of neurological disease. hNPCs survive and mature following transplanta...

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Autors principals: Gowing, Geneviève, Shelley, Brandon, Staggenborg, Kevin, Hurley, Amanda, Avalos, Pablo, Victoroff, Jesse, Latter, Jessica, Garcia, Leslie, Svendsen, Clive N.
Format: Artigo
Idioma:Inglês
Publicat: Lippincott Williams & Wilkins 2014
Matèries:
Engineered Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969154/
https://ncbi.nlm.nih.gov/pubmed/24284956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/WNR.0000000000000092
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