Mutant uromodulin expression leads to altered homeostasis of the endoplasmic reticulum and activates the unfolded protein response

Uromodulin is the most abundant urinary protein in physiological conditions. It is exclusively produced by renal epithelial cells lining the thick ascending limb of Henle’s loop (TAL) and it plays key roles in kidney function and disease. Mutations in UMOD, the gene encoding uromodulin, cause autoso...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Schaeffer, Céline, Merella, Stefania, Pasqualetto, Elena, Lazarevic, Dejan, Rampoldi, Luca
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402980/
https://ncbi.nlm.nih.gov/pubmed/28437467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0175970
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