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Mutant uromodulin expression leads to altered homeostasis of the endoplasmic reticulum and activates the unfolded protein response
Uromodulin is the most abundant urinary protein in physiological conditions. It is exclusively produced by renal epithelial cells lining the thick ascending limb of Henle’s loop (TAL) and it plays key roles in kidney function and disease. Mutations in UMOD, the gene encoding uromodulin, cause autoso...
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| Vydáno v: | PLoS One |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5402980/ https://ncbi.nlm.nih.gov/pubmed/28437467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0175970 |
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