Bidirectional KCNQ1:β-catenin interaction drives colorectal cancer cell differentiation

The K(+) channel KCNQ1 has been proposed as a tumor suppressor in colorectal cancer (CRC). We investigated the molecular mechanisms regulating KCNQ1:β-catenin bidirectional interactions and their effects on CRC differentiation, proliferation, and invasion. Molecular and pharmacologic approaches were...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Rapetti-Mauss, Raphael, Bustos, Viviana, Thomas, Warren, McBryan, Jean, Harvey, Harry, Lajczak, Natalia, Madden, Stephen F., Pellissier, Bernard, Borgese, Franck, Soriani, Olivier, Harvey, Brian J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402468/
https://ncbi.nlm.nih.gov/pubmed/28373572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702913114
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