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Genetic Otx2 mis-localization delays critical period plasticity across brain regions
Accumulation of non-cell autonomous Otx2 homeoprotein in postnatal mouse visual cortex (V1) has been implicated in both the onset and closure of critical period plasticity. Here, we show that a genetic point mutation in the glycosaminoglycan-recognition motif of Otx2 broadly delays the maturation of...
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| Publié dans: | Mol Psychiatry |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5400722/ https://ncbi.nlm.nih.gov/pubmed/28194008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2017.1 |
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