Genetic Otx2 mis-localization delays critical period plasticity across brain regions

Accumulation of non-cell autonomous Otx2 homeoprotein in postnatal mouse visual cortex (V1) has been implicated in both the onset and closure of critical period plasticity. Here, we show that a genetic point mutation in the glycosaminoglycan-recognition motif of Otx2 broadly delays the maturation of...

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Bibliografische gegevens
Gepubliceerd in:Mol Psychiatry
Hoofdauteurs: Lee, Henry Hing Cheong, Bernard, Clémence, Ye, Zhanlei, Acampora, Dario, Simeone, Antonio, Prochiantz, Alain, Di Nardo, Ariel A, Hensch, Takao K
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400722/
https://ncbi.nlm.nih.gov/pubmed/28194008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2017.1
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