Choroid plexus-derived Otx2 homeoprotein constrains adult cortical plasticity

Brain plasticity is often restricted to critical periods in early life. Here, we show that a key regulator of this process in visual cortex, Otx2 homeoprotein, is synthesized and secreted globally from the choroid plexus. Consequently, Otx2 is maintained in selected GABA cells unexpectedly throughou...

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Bibliografiske detaljer
Main Authors: Spatazza, Julien, Lee, Henry HC, Di Nardo, Ariel A, Tibaldi, Lorenzo, Joliot, Alain, Hensch, Takao K, Prochiantz, Alain
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119931/
https://ncbi.nlm.nih.gov/pubmed/23770240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.05.014
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