Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer

Rac GTPases have oncogenic roles in cell growth, survival, and migration. We tested response to the Rac inhibitor EHT1864 in a panel of breast cancer cell lines. EHT1864-induced growth inhibition was associated with dual inhibition of the PI3K/AKT/mTORC1 and MEK/ERK pathways. Breast cancer cells har...

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Publicado en:Oncotarget
Autores principales: Hampsch, Riley A., Shee, Kevin, Bates, Darcy, Lewis, Lionel D., Désiré, Laurent, Leblond, Bertrand, Demidenko, Eugene, Stefan, Kurtis, Huang, Yina H., Miller, Todd W.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400625/
https://ncbi.nlm.nih.gov/pubmed/28423521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15586
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