Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer

Rac GTPases have oncogenic roles in cell growth, survival, and migration. We tested response to the Rac inhibitor EHT1864 in a panel of breast cancer cell lines. EHT1864-induced growth inhibition was associated with dual inhibition of the PI3K/AKT/mTORC1 and MEK/ERK pathways. Breast cancer cells har...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Hampsch, Riley A., Shee, Kevin, Bates, Darcy, Lewis, Lionel D., Désiré, Laurent, Leblond, Bertrand, Demidenko, Eugene, Stefan, Kurtis, Huang, Yina H., Miller, Todd W.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400625/
https://ncbi.nlm.nih.gov/pubmed/28423521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15586
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados