Nucleosomes influence multiple steps during replication initiation

Eukaryotic replication origin licensing, activation and timing are influenced by chromatin but a mechanistic understanding is lacking. Using reconstituted nucleosomal DNA replication assays, we assessed the impact of nucleosomes on replication initiation. To generate distinct nucleosomal landscapes,...

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Veröffentlicht in:eLife
Hauptverfasser: Azmi, Ishara F, Watanabe, Shinya, Maloney, Michael F, Kang, Sukhyun, Belsky, Jason A, MacAlpine, David M, Peterson, Craig L, Bell, Stephen P
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2017
Schlagworte:
Biochemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400510/
https://ncbi.nlm.nih.gov/pubmed/28322723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22512
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