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The burden of trisomy 21 disrupts the proteostasis network in Down syndrome
Down syndrome (DS) is a genetic disorder caused by trisomy of chromosome 21. Abnormalities in chromosome number have the potential to lead to disruption of the proteostasis network (PN) and accumulation of misfolded proteins. DS individuals suffer from several comorbidities, and we hypothesized that...
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| Pubblicato in: | PLoS One |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5400264/ https://ncbi.nlm.nih.gov/pubmed/28430800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176307 |
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