The burden of trisomy 21 disrupts the proteostasis network in Down syndrome

Down syndrome (DS) is a genetic disorder caused by trisomy of chromosome 21. Abnormalities in chromosome number have the potential to lead to disruption of the proteostasis network (PN) and accumulation of misfolded proteins. DS individuals suffer from several comorbidities, and we hypothesized that...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Aivazidis, Stefanos, Coughlan, Christina M., Rauniyar, Abhishek K., Jiang, Hua, Liggett, L. Alexander, Maclean, Kenneth N., Roede, James R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2017
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400264/
https://ncbi.nlm.nih.gov/pubmed/28430800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176307
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