SNARE proteins rescue impaired autophagic flux in Down syndrome

Down syndrome (DS) is a chromosomal disorder caused by trisomy of chromosome 21 (Ts21). Unbalanced karyotypes can lead to dysfunction of the proteostasis network (PN) and disrupted proteostasis is mechanistically associated with multiple DS comorbidities. Autophagy is a critical component of the PN...

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發表在:PLoS One
Main Authors: Aivazidis, Stefanos, Jain, Abhilasha, Rauniyar, Abhishek K., Anderson, Colin C., Marentette, John O., Orlicky, David J., Fritz, Kristofer S., Harris, Peter S., Siegel, David, Maclean, Kenneth N., Roede, James R.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2019
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6850524/
https://ncbi.nlm.nih.gov/pubmed/31714914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0223254
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