Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population

Background: The antiretroviral nevirapine is associated with hypersensitivity reactions in 6%–10% of patients, including hepatotoxicity, maculopapular exanthema, Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Objectives: To undertake a genome-wide association study (GWAS) to id...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Carr, Daniel F., Bourgeois, Stephane, Chaponda, Mas, Takeshita, Louise Y., Morris, Andrew P., Castro, Elena M. Cornejo, Alfirevic, Ana, Jones, Andrew R., Rigden, Daniel J., Haldenby, Sam, Khoo, Saye, Lalloo, David G., Heyderman, Robert S., Dandara, Collet, Kampira, Elizabeth, van Oosterhout, Joep J., Ssali, Francis, Munderi, Paula, Novelli, Giuseppe, Borgiani, Paola, Nelson, Matthew R., Holden, Arthur, Deloukas, Panos, Pirmohamed, Munir
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400091/
https://ncbi.nlm.nih.gov/pubmed/28062682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkw545
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