CYP2B6 c.983T>C polymorphism is associated with nevirapine hypersensitivity in Malawian and Ugandan HIV populations

BACKGROUND: Nevirapine, an NNRTI used in HIV treatment, can cause hypersensitivity reactions in 6%–10% of patients. In the most serious cases (1.3%) this can manifest as Stevens–Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). METHODS: DNA samples were obtained and analysed from a total o...

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Detaylı Bibliyografya
Yayımlandı:J Antimicrob Chemother
Asıl Yazarlar: Carr, Daniel F., Chaponda, Mas, Cornejo Castro, Elena M., Jorgensen, Andrea L., Khoo, Saye, Van Oosterhout, Joep J., Dandara, Collet, Kampira, Elizabeth, Ssali, Francis, Munderi, Paula, Lalloo, David G., Heyderman, Robert S., Pirmohamed, Munir
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2014
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4228781/
https://ncbi.nlm.nih.gov/pubmed/25147095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dku315
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