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Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis

Mycolactone is the exotoxin virulence factor produced by Mycobacterium ulcerans, the pathogen responsible for Buruli ulcer. The skin lesions and immunosuppression that are characteristic of this disease result from the action of mycolactone, which targets the Sec61 complex and inhibits the co-transl...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: McKenna, Michael, Simmonds, Rachel E., High, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399781/
https://ncbi.nlm.nih.gov/pubmed/28219954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.198655
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