Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature

Mycolactone is a bacteria-derived macrolide that blocks the biogenesis of a large array of secretory and integral transmembrane proteins (TMP) through potent inhibition of the Sec61 translocon. Here, we used quantitative proteomics to delineate the direct and indirect effects of mycolactone-mediated...

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Foilsithe in:Mol Cell Proteomics
Main Authors: Morel, Jean-David, Paatero, Anja O., Wei, Jiajie, Yewdell, Jonathan W., Guenin-Macé, Laure, Van Haver, Delphi, Impens, Francis, Pietrosemoli, Natalia, Paavilainen, Ville O., Demangel, Caroline
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Biochemistry and Molecular Biology 2018
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126388/
https://ncbi.nlm.nih.gov/pubmed/29915147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA118.000824
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