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Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone

The virulence factor mycolactone is responsible for the immunosuppression and tissue necrosis that characterise Buruli ulcer, a disease caused by infection with Mycobacterium ulcerans. In this study, we confirm that Sec61, the protein-conducting channel that coordinates entry of secretory proteins i...

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Detaylı Bibliyografya
Yayımlandı:J Cell Sci
Asıl Yazarlar: McKenna, Michael, Simmonds, Rachel E., High, Stephen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Company of Biologists Ltd 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852723/
https://ncbi.nlm.nih.gov/pubmed/26869228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.182352
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