Simultaneous targeting of CD44 and EpCAM with a bispecific aptamer effectively inhibits intraperitoneal ovarian cancer growth

CD44 and EpCAM play crucial roles in intraperitoneal ovarian cancer development. In this study, we developed an RNA-based bispecific CD44-EpCAM aptamer that is capable of blocking CD44 and EpCAM simultaneously by fusing single CD44 and EpCAM aptamers with a double stranded RNA adaptor. With the aid...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Zheng, Jingying, Zhao, Shuhua, Yu, Xiaolin, Huang, Shuang, Liu, Hong Yan
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399600/
https://ncbi.nlm.nih.gov/pubmed/28435472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.17826
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