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Mycobacterium tuberculosis Cpn60.2 (GroEL2) blocks macrophage apoptosis via interaction with mitochondrial mortalin

Earlier studies suggested that Mycobacterium tuberculosis (Mtb) proteins exported within the host macrophage play an essential role in tuberculosis pathogenesis. In fact, Mtb proteins interact with and deactivate key regulators of many macrophage functions such as phago-lysosome fusion and antigen p...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Biol Open
Hauptverfasser: Joseph, Sunil, Yuen, Alex, Singh, Vijender, Hmama, Zakaria
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399554/
https://ncbi.nlm.nih.gov/pubmed/28288970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.023119
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