A Class of Reactive Acyl-CoA Species Reveals the Non-Enzymatic Origins of Protein Acylation

The mechanisms underlying the formation of acyl protein modifications remain poorly understood. By investigating the reactivity of endogenous acyl-CoA metabolites, we found a class of acyl-CoAs that undergoes intramolecular catalysis to form reactive intermediates which non-enzymatically modify prot...

詳細記述

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書誌詳細
出版年:Cell Metab
主要な著者: Wagner, Gregory R., Bhatt, Dhaval P., O’Connell, Thomas M., Thompson, J. Will, Dubois, Laura G., Backos, Donald S., Yang, Hao, Mitchell, Grant A., Ilkayeva, Olga R., Stevens, Robert D., Grimsrud, Paul A., Hirschey, Matthew D.
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399522/
https://ncbi.nlm.nih.gov/pubmed/28380375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.03.006
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