A Class of Reactive Acyl-CoA Species Reveals the Non-Enzymatic Origins of Protein Acylation

The mechanisms underlying the formation of acyl protein modifications remain poorly understood. By investigating the reactivity of endogenous acyl-CoA metabolites, we found a class of acyl-CoAs that undergoes intramolecular catalysis to form reactive intermediates which non-enzymatically modify prot...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Wagner, Gregory R., Bhatt, Dhaval P., O’Connell, Thomas M., Thompson, J. Will, Dubois, Laura G., Backos, Donald S., Yang, Hao, Mitchell, Grant A., Ilkayeva, Olga R., Stevens, Robert D., Grimsrud, Paul A., Hirschey, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399522/
https://ncbi.nlm.nih.gov/pubmed/28380375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.03.006
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