A Class of Reactive Acyl-CoA Species Reveals the Non-Enzymatic Origins of Protein Acylation

The mechanisms underlying the formation of acyl protein modifications remain poorly understood. By investigating the reactivity of endogenous acyl-CoA metabolites, we found a class of acyl-CoAs that undergoes intramolecular catalysis to form reactive intermediates which non-enzymatically modify prot...

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Bibliographic Details
Published in:Cell Metab
Main Authors: Wagner, Gregory R., Bhatt, Dhaval P., O’Connell, Thomas M., Thompson, J. Will, Dubois, Laura G., Backos, Donald S., Yang, Hao, Mitchell, Grant A., Ilkayeva, Olga R., Stevens, Robert D., Grimsrud, Paul A., Hirschey, Matthew D.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399522/
https://ncbi.nlm.nih.gov/pubmed/28380375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.03.006
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