Natriuretic peptide receptor guanylyl cyclase-A pathway counteracts glomerular injury evoked by aldosterone through p38 mitogen-activated protein kinase inhibition

Guanylyl cyclase-A (GC-A) signaling, a natriuretic peptide receptor, exerts renoprotective effects by stimulating natriuresis and reducing blood pressure. Previously we demonstrated massive albuminuria with hypertension in uninephrectomized, aldosterone-infused, and high salt-fed (ALDO) systemic GC-...

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Pubblicato in:Sci Rep
Autori principali: Kato, Yukiko, Mori, Kiyoshi, Kasahara, Masato, Osaki, Keisuke, Ishii, Akira, Mori, Keita P., Toda, Naohiro, Ohno, Shoko, Kuwabara, Takashige, Tokudome, Takeshi, Kishimoto, Ichiro, Saleem, Moin A., Matsusaka, Taiji, Nakao, Kazuwa, Mukoyama, Masashi, Yanagita, Motoko, Yokoi, Hideki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399490/
https://ncbi.nlm.nih.gov/pubmed/28429785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46624
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