Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure

Pharmacological blockade of the N- and L-type calcium channel lessens renal injury in kidney disease patients. The significance of specific blockade of α1 subunit of N-type calcium channel, Ca(v)2.2, in diabetic nephropathy, however, remains to be clarified. To examine functional roles, we mated Ca(...

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Pubblicato in:Sci Rep
Autori principali: Ohno, Shoko, Yokoi, Hideki, Mori, Kiyoshi, Kasahara, Masato, Kuwahara, Koichiro, Fujikura, Junji, Naito, Masaki, Kuwabara, Takashige, Imamaki, Hirotaka, Ishii, Akira, Saleem, Moin A., Numata, Tomohiro, Mori, Yasuo, Nakao, Kazuwa, Yanagita, Motoko, Mukoyama, Masashi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4895143/
https://ncbi.nlm.nih.gov/pubmed/27273361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27192
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