Verteporfin-induced formation of protein cross-linked oligomers and high molecular weight complexes is mediated by light and leads to cell toxicity

Verteporfin (VP) was first used in Photodynamic therapy, where a non-thermal laser light (689 nm) in the presence of oxygen activates the drug to produce highly reactive oxygen radicals, resulting in local cell and tissue damage. However, it has also been shown that Verteporfin can have non-photoact...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Konstantinou, Eleni K., Notomi, Shoji, Kosmidou, Cassandra, Brodowska, Katarzyna, Al-Moujahed, Ahmad, Nicolaou, Fotini, Tsoka, Pavlina, Gragoudas, Evangelos, Miller, Joan W., Young, Lucy H., Vavvas, Demetrios G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399488/
https://ncbi.nlm.nih.gov/pubmed/28429726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46581
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