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Regulation of inducible nitric oxide synthase by rapid cellular turnover and cotranslational down-regulation by dimerization inhibitors

Overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) has been implicated in the pathogenesis of many disorders. iNOS is notably distinguished from constitutive NOSs by its production of large amounts of NO for a prolonged period; hence, it was termed the high-output NOS. Und...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Kolodziejski, Pawel J., Koo, Ja-Seok, Eissa, N. Tony
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
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Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC539786/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15601772/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0406711102
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