Development of a high-titer retrovirus producer cell line capable of gene transfer into rhesus monkey hematopoietic stem cells.

Retroviral-mediated gene transfer into primitive hematopoietic cells has been difficult to achieve in large-animal models. We have developed an amphotropic producer clone that generates greater than 10(10) recombinant retroviral particles (colony-forming units) per ml of culture medium. Autologous r...

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Bibliografiska uppgifter
Huvudupphovsmän: Bodine, D M, McDonagh, K T, Brandt, S J, Ney, P A, Agricola, B, Byrne, E, Nienhuis, A W
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1990
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC53978/
https://ncbi.nlm.nih.gov/pubmed/2339117
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