NS5B Promotes Degradation of the NORE1A Tumor Suppressor to Facilitate Hepatitis C Virus Replication

Hepatitis C infection is a common risk factor for the development of liver cancer. The molecular mechanisms underlying this effect are only partially understood. Here we show that the HCV protein NS5B directly binds to the tumor suppressor NORE1A (RASSF5) and promotes its proteosomal degradation. In...

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Detaylı Bibliyografya
Yayımlandı:Hepatology
Asıl Yazarlar: Arora, Payal, Basu, Amartya, Schmidt, M. Lee, Clark, Geoffrey J., Donninger, Howard, Nichols, Daniel B., Calvisi, Diego F., Kaushik-Basu, Neerja
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397368/
https://ncbi.nlm.nih.gov/pubmed/28090674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29049
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